Photocatalytic glucose-appended bio-compatible Ir(<scp>iii</scp>) anticancer complexes
Zilin Zhu, Li Wei, Yidan Lai, Oliver W. L. Carter, Samya Banerjee, Peter J. Sadler, Huaiyi Huang
Abstract
biocompatible complex, Ir3, shows lysosome and mitochondria targeting necro-apoptotic photo-cytotoxicity against various cancer cell lines and multicellular spheroids, while remaining non-toxic in the dark.
Topics & Concepts
ChemistryCatalysisCytotoxicityPhotocatalysisAqueous solutionIridiumBiocompatible materialIn vivoVisible spectrumNAD+ kinaseStereochemistryCombinatorial chemistryBiochemistryIn vitroOrganic chemistryMaterials scienceEnzymeBiotechnologyOptoelectronicsMedicineBiomedical engineeringBiologyNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisClick Chemistry and Applications