The fates of internalized NaV1.7 channels in sensory neurons: Retrograde cotransport with other ion channels, axon-specific recycling, and degradation
Grant P. Higerd‐Rusli, Sidharth Tyagi, Shujun Liu, Fadia B. Dib-Hajj, Stephen G. Waxman, Sulayman D. Dib‐Hajj
Abstract
1.7 is recycled specifically to the axonal membrane as opposed to the soma membrane, suggesting a novel mechanism for the development of neuronal polarity. Together, these results shed light on the mechanisms by which neurons maintain excitable membranes and may inform efforts to target ion channel trafficking for the treatment of disorders of excitability.
Topics & Concepts
EndocytosisCell biologyIon channelSodium channelEndosomeAxonSomaBulk endocytosisNeuroscienceAxoplasmic transportBiologyChemistryEndocytic cycleCellIntracellularBiochemistryReceptorSodiumOrganic chemistryCellular transport and secretionIon channel regulation and functionVenomous Animal Envenomation and Studies