Circadian regulation of microglia function: Potential targets for treatment of Parkinson’s Disease
Liang Kou, Xiaosa Chi, Yadi Sun, Sijia Yin, Jiawei Wu, Wenkai Zou, Yiming Wang, Zongjie Jin, Jinsha Huang, Nian Xiong, Yun Xia, Tao Wang
Abstract
Circadian rhythms are involved in the regulation of many aspects of the body, including cell function, physical activity and disease. Circadian disturbance often predates the typical symptoms of neurodegenerative diseases and is not only a non-motor symptom, but also one of the causes of their occurrence and progression. Glial cells possess circadian clocks that regulate their function to maintain brain development and homeostasis. Emerging evidence suggests that the microglial circadian clock is involved in the regulation of many physiological processes, such as cytokine release, phagocytosis, and nutritional and metabolic support, and that disruption of the microglia clock may affect multiple aspects of Parkinson's disease, especially neuroinflammation and α-synuclein processes. Herein, we review recent advances in the circadian control of microglia function in health and disease, and discuss novel pharmacological interventions for microglial clocks in neurodegenerative disorders.