Design, synthesis, and analysis of antiproliferative and apoptosis-inducing activities of nitrile derivatives containing a benzofuran scaffold: EGFR inhibition assay and molecular modelling study
Salma Fares, Khalid B. Selim, Fatma E. Goda, Magda A.‐A. El‐Sayed, Nawaf A. Alsaif, Mohamed Hefnawy, Alaa A.‐M. Abdel‐Aziz, Adel S. El‐Azab
Abstract
indicated that they could bind to the active site of EGFR TK.
Topics & Concepts
ChemistryIC50GefitinibBenzofuranEGFR inhibitorsApoptosisDocking (animal)StereochemistryCell cycle checkpointAfatinibPharmacologyCell cycleEpidermal growth factor receptorBiochemistryIn vitroReceptorBiologyMedicineNursingHER2/EGFR in Cancer ResearchLung Cancer Treatments and MutationsQuinazolinone synthesis and applications