Palladium-catalyzed regio- and stereoselective allylic alkylation of 5-vinyloxazolidine-2,4-diones with azlactones: synthesis of chiral (<i>Z</i>)-trisubstituted allylic amino acid derivatives
Kuan Li, Lan Wang, Shuo Zhen, Lihan Zhu, Songcheng Yu, Yongjun Wu, Hongchao Guo
Abstract
Palladium-catalyzed regio- and stereoselective allylic alkylation of 5-vinyloxazolidine-2,4-diones with azlactones worked well to give the Z configuration of various trisubstituted allylic amino acid derivatives.
Topics & Concepts
StereoselectivityChemistryTsuji–Trost reactionAllylic rearrangementPalladiumCatalysisAlkylationOrganic chemistryStereochemistryMedicinal chemistryAsymmetric Synthesis and CatalysisSynthetic Organic Chemistry MethodsCyclopropane Reaction Mechanisms