<i>In Situ</i> Visualization of the pKM101-Encoded Type IV Secretion System Reveals a Highly Symmetric ATPase Energy Center
Pratick Khara, Liqiang Song, Peter J. Christie, Bo Hu
Abstract
analyses of the T4SS nanomachines and support a unified model in which the signature VirB4 ATPases of the T4SS superfamily function as a central hexamer of dimers to regulate early-stage machine biogenesis and substrate entry passage through the T4SS. The VirB4 ATPases are therefore excellent targets for the development of intervention strategies aimed at suppressing the action of T4SS nanomachines.
Topics & Concepts
SecretionContext (archaeology)VirulencePlasmidEnvelope (radar)Cell biologyBiologyChemistryMicrobiologyDNAComputer scienceGeneticsBiochemistryGenePaleontologyTelecommunicationsRadarAntibiotic Resistance in BacteriaEscherichia coli research studiesBacterial Genetics and Biotechnology