Synthesis and characterization of a stable and inert Mn<sup>II</sup>-based Zn<sup>II</sup> responsive MRI probe for molecular imaging of glucose stimulated zinc secretion (GSZS)
Richárd Botár, Enikő Molnár, Zoltán Garda, Enikő Madarasi, György Trencsényi, János Kiss, Ferenc K. Kálmán, Gyula Tircsó
Abstract
A Zn II responsive Mn II -based MRI contrast agent, [Mn(PC2A-DPA)], has been synthesized, investigated and applied in imaging studies. It shows high stability and excellent inertness and can be used to visualize glucose triggered Zn II release by MRI.
Topics & Concepts
ZincChemistryCharacterization (materials science)InertNuclear chemistryRadiochemistryMaterials scienceNanotechnologyOrganic chemistryLanthanide and Transition Metal ComplexesAdvanced MRI Techniques and ApplicationsMagnetism in coordination complexes