<i>Zizyphus mauritiana</i> Fruit Extract-Mediated Synthesized Silver/Silver Chloride Nanoparticles Retain Antimicrobial Activity and Induce Apoptosis in MCF-7 Cells through the Fas Pathway
Syed Rashel Kabir, A.K.M. Asaduzzaman, Ruhul Amin, ASM Tanbirul Haque, Rita Ghose, Md. Musfikur Rahman, Jahanur Islam, Md. Boni Amin, Imtiaj Hasan, Tapas Debnath, Byung‐Soo Chun, Xudong Zhao, M.K.R. Khan, Mohammad Taufiq Alam
Abstract
values of 28 and 84 μg/mL, respectively. No colony was formed in MCF-7 cells in the presence of these nanoparticles as compared with control. Ag/AgCl-NPs induced apoptosis and generated ROS in MCF-7 cells. The expression level of FAS, FADD, and caspase-8 genes increased several folds with the decrease of PARP gene expression. These results demonstrated that the anti-proliferation activity of Ag/AgCl-NPs against MCF-7 cells resulted through ROS generation and induction of apoptosis through the Fas-mediated pathway.
Topics & Concepts
Nuclear chemistrySilver nanoparticleChemistryReactive oxygen speciesEhrlich ascites carcinomaAntibacterial activityAntimicrobialNanoparticleMaterials scienceBiochemistryBiologyBacteriaNanotechnologyOrganic chemistryGeneticsIn vitroNanoparticles: synthesis and applicationsZiziphus Jujuba Studies and ApplicationsMoringa oleifera research and applications