Design, synthesis and molecular modeling of new quinazolin-4(3H)-one based VEGFR-2 kinase inhibitors for potential anticancer evaluation
Abdallah E. Abdallah, Sally I. Eissa, Maged Mohammed Saleh Al Ward, Reda R. Mabrouk, Ahmed B. M. Mehany, Mohamed Ayman El‐Zahabi
Topics & Concepts
ChemistryKinaseIC50Docking (animal)In vitroCell cultureThio-Tyrosine kinaseApoptosisCancer cellStereochemistryBiochemistryCombinatorial chemistryCancerSignal transductionBiologyNursingGeneticsMedicineQuinazolinone synthesis and applicationsHER2/EGFR in Cancer ResearchSynthesis and biological activity