Single-cell analysis of human thymus and peripheral blood unveils the dynamics of T cell development and aging
Yujun Deng, Zhengcan Peng, Kang Ming, Xiaona Qiao, Bin Ye, Yan Liu, Haiyue Wang, Peng Yang, Yu Zhang, Kun Zhou, Quanwei Huang, Wei Guo, Yi Xie, Hong Chen, Hui Yu, Liangbin Lin, Xinkai Zou, Keyue Wang, Pengbo Guan, Birong Dong, Xiaolong Chen, Xiaowen Wang, Jia Hu, Yuzhang Wu, Huiyuan Zhang, Hongbo Hu
Topics & Concepts
BiologyThymic involutionT cellCD8ImmunologyT-cell receptorImmune systemNaive T cellInvolution (esoterism)T lymphocyteCell biologyRepertoireReceptorImmunosenescenceCD38Cytotoxic T cellPeripheral bloodProgenitor cellCellInnate immune systemStem cellMemory T cellCellular differentiationAcquired immune systemLymphopoiesisTranscriptomeSingle-cell and spatial transcriptomicsT-cell and B-cell ImmunologyAtherosclerosis and Cardiovascular Diseases