A photoactivated Ir(<scp>iii</scp>) complex targets cancer stem cells and induces secretion of damage-associated molecular patterns in melanoma cells characteristic of immunogenic cell death
Gloria Vigueras, Lenka Marková, Vojtěch Novohradský, Alicia Marco, N. Cutillas, Hana Kostrhunová, Jana Kašpárková, José Ruiz, Viktor Brabec
Abstract
The new iridium complex selectively targets cancer stem cells and has potential to induce immunogenic cell death in cancer cells.
Topics & Concepts
SecretionCancer cellMelanomaChemistryCell biologyProgrammed cell deathCancer stem cellStem cellCancer researchTumor cellsCancerBiologyApoptosisBiochemistryGeneticsImmunotherapy and Immune ResponsesNanoplatforms for cancer theranosticsCancer Immunotherapy and Biomarkers