A ligand-free copper-catalyzed strategy to the N-arylation of indazole using aryl bromides
Di-Xiang Bai, Rachel Sin-Ee Lim, Huifen Ng, Yong‐Chua Teo
Abstract
A simple and efficient strategy for the C–N cross-coupling of indazole with a variety of substituted aryl bromides is reported. Under the optimized conditions, a broad scope of N-arylated products were obtained in good to excellent yields (up to 87%) under the ligand-free conditions.
Topics & Concepts
IndazoleChemistryArylLigand (biochemistry)CatalysisCombinatorial chemistryCopperScope (computer science)Organic chemistryReceptorBiochemistryAlkylComputer scienceProgramming languageCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques