Building <i>Streptomyces albus</i> as a chassis for synthesis of bacterial terpenoids
Yi Ling Hu, Qi Zhang, Shuang He Liu, Jia Sun, Fang Zhou Yin, Zi Ru Wang, Jing Shi, Rui Jiao, Hui Ming Ge
Abstract
We built a Streptomyces expression system to discovery bacterial terpenoids. Though genome mining and expression of terpene BGCs, 11 terpene skeletons including 3 new ones, and 18 novel distinct terpenoids were isolated and characterized.
Topics & Concepts
TerpenoidTerpeneStreptomycesBiologyChassisGeneActinobacteriaBiochemistryBacteriaGeneticsEngineeringStructural engineering16S ribosomal RNAPlant biochemistry and biosynthesisMicrobial Natural Products and BiosynthesisPhytochemical compounds biological activities