Construction and Analysis of the Complete Genome Sequence of Leprosy Agent Mycobacterium lepromatosis
Francisco J. Silva, Diego Santos-García, Xiaofeng Zheng, Li Zhang, Xiang Y. Han
Abstract
Leprosy is a dreaded infection that still affects millions of people worldwide. Mycobacterium lepromatosis is a recently recognized cause in addition to the well-known Mycobacterium leprae . M. lepromatosis is likely specific for diffuse lepromatous leprosy, a severe form of the infection and endemic in Mexico. This study constructed and annotated the complete genome sequence of M. lepromatosis FJ924 and performed comparative genomic analyses with related mycobacteria.
Topics & Concepts
LeprosyMycobacterium lepraeMycobacteriumSequence (biology)GenomeWhole genome sequencingBiologySequence analysisGeneticsMicrobiologyVirologyImmunologyGeneBacteriaMycobacterium research and diagnosisLeprosy Research and TreatmentTuberculosis Research and Epidemiology