Gastric Non-Helicobacter pylori Urease-Positive Staphylococcus epidermidis and Streptococcus salivarius Isolated from Humans Have Contrasting Effects on H. pylori-Associated Gastric Pathology and Host Immune Responses in a Murine Model of Gastric Cancer
Zeli Shen, JoAnn Dzink-Fox, Feng Yan, Sureshkumar Muthupalani, Anthony Mannion, Alexander Sheh, Mark T. Whary, Hilda Holcombe, Blanca Piazuelo, Luis Eduardo Bravo, Christine Josenhans, Sebastian Suerbaum, Keith T. Wilson, Richard M. Peek, Timothy C. Wang, James G. Fox
Abstract
coinfection with H. pylori induced significantly higher gastric pathology than in H. pylori-monoinfected mice, whereas S. epidermidis coinfection caused significantly lower H. pylori-induced proinflammatory cytokine responses than in H. pylori-monoinfected mice. This study reinforces the argument that the non-H. pylori stomach microflora play a role in the severity of H. pylori-induced gastric cancer.
Topics & Concepts
Streptococcus salivariusHelicobacter pyloriImmune systemCancerImmunologyMicrobiologyStaphylococcus epidermidisUreaseBiologyMedicineStreptococcusStaphylococcus aureusGastroenterologyInternal medicineBacteriaEnzymeGeneticsBiochemistryHelicobacter pylori-related gastroenterology studiesGastric Cancer Management and OutcomesMicrobial Metabolites in Food Biotechnology