Sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes
Maria Tsingas, Olivia K. Ottone, Abdul Haseeb, Ruteja A. Barve, Irving M. Shapiro, Véronique Lefebvre, Makarand V. Risbud
Topics & Concepts
SOX9NotochordExtracellular matrixCell biologyIntervertebral discBiologyChondrocyteCompartment (ship)Degeneration (medical)Transcription factorAnatomyPathologyCartilageEmbryoGeneticsMedicineEmbryogenesisGeneGeologyOceanographySpine and Intervertebral Disc PathologyOsteoarthritis Treatment and MechanismsTGF-β signaling in diseases