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Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway

Junbing Zhang, Claire Simpson, Jacqueline Berner, Harrison B. Chong, Jiafeng Fang, Zehra Ordulu, Tommy Weiss‐Sadan, Anthony Possemato, Stefan Harry, Mariko Takahashi, Tzu-yi Yang, Marianne Richter, Himani Patel, Abby E. Smith, Alexander Carlin, Adriaan F. Hubertus de Groot, Konstantin Wolf, Lei Shi, Ting-Yu Wei, Benedikt R. Dürr, Nicholas J. Chen, Tristan Vornbäumen, Nina Olivera Wichmann, Mohammed Mahamdeh, Venkatesh Pooladanda, Yusuke Matoba, Shaan Kumar, Eugene Kim, Sara Bouberhan, Esther Oliva, Bo R. Rueda, Roy J. Soberman, Nabeel Bardeesy, Brian B. Liau, Michael S. Lawrence, Matt P. Stokes, Sean A. Beausoleil, Liron Bar‐Peled

2023Cell143 citationsDOIOpen Access PDF

Topics & Concepts

BiologyMitochondrionNucleusIdentification (biology)Cell biologyDrugAnticancer drugComputational biologyPharmacologyBotanyMitochondrial Function and PathologyATP Synthase and ATPases ResearchRedox biology and oxidative stress
Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway | Litcius