Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway
Junbing Zhang, Claire Simpson, Jacqueline Berner, Harrison B. Chong, Jiafeng Fang, Zehra Ordulu, Tommy Weiss‐Sadan, Anthony Possemato, Stefan Harry, Mariko Takahashi, Tzu-yi Yang, Marianne Richter, Himani Patel, Abby E. Smith, Alexander Carlin, Adriaan F. Hubertus de Groot, Konstantin Wolf, Lei Shi, Ting-Yu Wei, Benedikt R. Dürr, Nicholas J. Chen, Tristan Vornbäumen, Nina Olivera Wichmann, Mohammed Mahamdeh, Venkatesh Pooladanda, Yusuke Matoba, Shaan Kumar, Eugene Kim, Sara Bouberhan, Esther Oliva, Bo R. Rueda, Roy J. Soberman, Nabeel Bardeesy, Brian B. Liau, Michael S. Lawrence, Matt P. Stokes, Sean A. Beausoleil, Liron Bar‐Peled
Topics & Concepts
BiologyMitochondrionNucleusIdentification (biology)Cell biologyDrugAnticancer drugComputational biologyPharmacologyBotanyMitochondrial Function and PathologyATP Synthase and ATPases ResearchRedox biology and oxidative stress