Box–Behnken design of thermo-responsive nano-liposomes loaded with a platinum(<scp>iv</scp>) anticancer complex: evaluation of cytotoxicity and apoptotic pathways in triple negative breast cancer cells
Nada K. Sedky, Maria Braoudaki, Noha Khalil Mahdy, Kenzy Amin, Iten M. Fawzy, Eleni Κ. Efthimiadou, R.A. Youness, Sherif Ashraf Fahmy
Abstract
by 70% and 85%, respectively. As such, the optimal Asp TLs (40 °C) treatment displayed the most potent cytotoxic profile and induced both apoptosis and necrosis in MDA-MB-231.
Topics & Concepts
CytotoxicityMTT assayApoptosisIC50Box–Behnken designChemistryCytotoxic T cellHyperthermiaPopulationTriple-negative breast cancerCancer cellMolecular biologyChromatographyCancerBiochemistryBreast cancerIn vitroBiologyMedicineResponse surface methodologyInternal medicineEnvironmental healthNanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryNanoplatforms for cancer theranostics