EVALUATION OF ANTIBACTERIAL AND ANTIOXIDANT ACTIVITIES OF XANTHONE ISOLATED FROM Orophea corymbosa LEAF
Hawa Purnama Celala Ary Cane, Nurdin Saidi, M. Mustanir, Darusman Darusman, Rinaldi Idroes, Musri Musman
Abstract
The pharmacological properties (antibacterial and antioxidant) of the ethyl acetate extract from the leaves of Orophea corymbosa Blume Miq. the plant was evaluated and continued for obtaining bioactive compounds through the isolation process. A pure isolate from ethyl acetate extract was analyzed of structure compound using NMR Spectra, FTIR, UV-Vis, and MS (GCMS). An isolated compound was considered to be xanthone derived compound, namely 1hydroxy-2,3-dimethoxyxanthone. Its activities against Gram-negative and positive bacteria were examined with bioindicator Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923, respectively, where the results were then compared to cephazolin; and antioxidant activity with indicator free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) compared to ascorbic acid. The xanthone compound has good activity as antibacterial and antioxidant. The plant has administrated the potential for handling bacteria and free radicals in this study.