Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice
Lü Ren, Wa Du, Dan Song, Haocheng Lu, Milton H. Hamblin, Chenran Wang, Chunying Du, Guo‐Chang Fan, Richard C. Becker, Yanbo Fan
Abstract
KO significantly inhibited the inflammatory response and suppressed the NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome in WAT. Altogether, we demonstrated the critical role of CCDC92 in metabolism, constituting a potential target for treating obesity and insulin resistance.
Topics & Concepts
Insulin resistanceEndocrinologyInternal medicineType 2 diabetesAdipose tissueObesityWhite adipose tissueInflammasomeGenome-wide association studyFibrosisBiologySteatosisDiabetes mellitusKnockout mouseInsulinMedicineInflammationGeneSingle-nucleotide polymorphismGeneticsReceptorGenotypeAdipokines, Inflammation, and Metabolic DiseasesEndoplasmic Reticulum Stress and DiseaseAdipose Tissue and Metabolism