Cobalt-Catalyzed Selective Hydroboration of 1,3-Enynes with HBpin toward 1,3-Dienylboronate Esters
Yining Jia, Liu Yang, Xue‐Qiang Wang, Wen Yang, Wanxiang Zhao
Abstract
An efficient cobalt-catalyzed selective hydroboration of 1,3-enynes with HBpin toward 1,3-dienylboronate esters is disclosed. With a commercially available catalytic system of Co(acac) 2 and dppf, the hydroboration reactions proceeded well to afford a wide range of 1,3-dienylborates in moderate to high yields. This protocol features a cheap base-metal catalytic system, broad substrate scope, excellent selectivity, easy gram-scale preparation, and good functional group tolerance and provides access to synthetically valuable 1,3-dienylborates.
Topics & Concepts
HydroborationChemistryCatalysisCobaltCombinatorial chemistrySubstrate (aquarium)Functional groupSelectivityScope (computer science)Organic chemistryGeologyProgramming languageComputer sciencePolymerOceanographyOrganoboron and organosilicon chemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization Methods