Inhibition of CYP2E1 and activation of Nrf2 signaling pathways by a fraction from Entada africana alleviate carbon tetrachloride-induced hepatotoxicity
Arnaud Fondjo Kouam, Brice Ayissi Owona, Rodrigue Fifen, Frédéric Nico Njayou, Paul Fewou Moundipa
Abstract
-induced hepatotoxicity, likely through inhibition of CYP2E1 and activation of the Nrf2 signaling pathway.
Topics & Concepts
Carbon tetrachlorideCYP2E1Signal transductionFraction (chemistry)PharmacologyChemistryCell biologyBiochemistryTraditional medicineMedicineBiologyEnzymeCytochrome P450Organic chemistryDrug-Induced Hepatotoxicity and ProtectionLiver Disease Diagnosis and TreatmentDrug Transport and Resistance Mechanisms