P2RX7 at the Host-Pathogen Interface of Infectious Diseases
Alexandra Y. Soare, Tracey Freeman, Alice K. Min, Hagerah S. Malik, Elizabeth O. Osota, Talia H. Swartz
Abstract
evidence for the critical role these receptors play in mediating and modulating immune responses. Our observations indicate a role for P2X7 signaling in sensing damage-associated molecular patterns released by nearby infected cells to facilitate immunopathology or protection. In this review, we describe how P2RX7 signaling can play critical roles in numerous cells types in response to a diverse array of pathogens in mediating pathogenesis and immunity to infectious agents.
Topics & Concepts
BiologyPathogenImmune systemExtracellularReceptorHost (biology)MicrobiologyImmunologyCell biologyGeneticsAdenosine and Purinergic SignalingCOVID-19 Impact on ReproductionAdolescent and Pediatric Healthcare