Effect of Natriuretic Peptide–Guided Therapy on Hospitalization or Cardiovascular Mortality in High-Risk Patients With Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial
Kirkwood F. Adams, Patrice Desvigne‐Nickens, Ileana L. Piña, Gayle M. Passmore, Christopher M. O’Connor, G. Michael Felker, Hongqiu Yang, David J. Whellan, Kevin J. Anstrom, Lawton S. Cooper, Eric Leifer, Justin A. Ezekowitz, James L. Januzzi, Daniel B. Mark, Mona Fiuzat, Nancy Houston-Miller
Abstract
The natriuretic peptides are biochemical markers of heart failure (HF) severity and predictors of adverse outcomes. Smaller studies have evaluated adjusting HF therapy based on natriuretic peptide levels (“guided therapy”) with inconsistent results.
Topics & Concepts
Ejection fractionHeart failureMedicineInternal medicineRandomized controlled trialCardiologyNatriuretic peptideBrain natriuretic peptideHeart Failure Treatment and Management