Subtle change of fibrillation condition leads to substantial alteration of recombinant Tau fibril structure
Xiang Li, Shenqing Zhang, Zhengtao Liu, Youqi Tao, Wencheng Xia, Yunpeng Sun, Cong Liu, Weidong Le, Bo Sun, Dan Li
Abstract
assembled fibrils prior to further laboratory use.
Topics & Concepts
FibrilAmyloid fibrilIn vitroChemistryBiophysicsAmyloid (mycology)Protein filamentTau pathologyCryo-electron microscopyAmyloid βCrystallographyBiochemistryAlzheimer's diseaseBiologyPathologyDiseaseMedicineInorganic chemistryAlzheimer's disease research and treatmentsPrion Diseases and Protein MisfoldingSupramolecular Self-Assembly in Materials