Dietary limonin ameliorates heart failure with preserved ejection fraction by targeting ferroptosis <i>via</i> modulation of the Nrf2/SLC7A11/GPX4 axis: an integrated transcriptomics and metabolomics analysis
Xiaoqi Wei, Xinyi Fan, Wangjing Chai, Jinling Xiao, Jiong Zhao, Aina He, Xianwen Tang, Fanghe Li, Shuzhen Guo
Abstract
Limonin ameliorates HFpEF by attenuating cardiac remodeling while inhibiting ferroptosis through activation of the Nrf2/SLC7A11/GPX4 axis and inhibition of ACSL4/COX2/ALOXs-mediated lipid peroxidation, as validated by multi-omics analyses.
Topics & Concepts
Ejection fractionHeart failureCardiologyInternal medicineMetabolomicsMedicineDiastolic functionHeart failure with preserved ejection fractionDiastoleBiologyBioinformaticsBlood pressureFerroptosis and cancer prognosisMicroRNA in disease regulationCancer-related molecular mechanisms research