Genetic diversity estimates for the Caenorhabditis Intervention Testing Program screening panel
Anastasia Teterina, Anna L Coleman-Hulbert, Stephen A. Banse, John H. Willis, Viviana Pérez, Gordon J. Lithgow, Monica Driscoll, Patrick C. Phillips
Abstract
strains (2.6e-3) greater than estimates for human populations, and comparable to that found in mouse populations. Our analysis supports the assumption that the CITP screening panel encompasses broad genetic diversity, suggesting that lifespan-extending chemicals with efficacy across the panel should be enriched for interventions that function on conserved processes that are shared across genetic backgrounds. While the diversity panel was established by the CITP for studying longevity interventions, the panel may prove useful for the broader research community when seeking broadly efficacious interventions for any phenotype with potential genetic background effects.