Design, synthesis and biological evaluations of diverse Michael acceptor-based phenazine hybrid molecules as TrxR1 inhibitors
Yucheng Zhong, Jing Liu, Xiangyu Cheng, Hao Zhang, Chunhua Zhang, Zhuolu Xia, Zhongxi Wu, Lu Zhang, Yuting Zheng, Zhanyu Gao, Zhidong Jiang, Zhixiang Wang, Dechun Huang, Yuanyuan Lu, Feng Jiang
Topics & Concepts
ChemistryApoptosisCytotoxicityPhenazineIntracellularCell cultureTransfectionIn vitrop38 mitogen-activated protein kinasesCell biologyEnzymeBiochemistryBiologyGeneProtein kinase AGeneticsBioactive Compounds and Antitumor AgentsGenomics, phytochemicals, and oxidative stressRedox biology and oxidative stress