Synthesis and <i>in vitro</i> photodynamic activity of aza-BODIPY-based photosensitizers
Tamás Hlogyik, Réka Laczkó-Rigó, Éva Bakos, Miklós Poór, Zoltán Kele, Csilla Özvegy‐Laczka, Erzsébet Mernyák
Abstract
photodynamic activities of the newly synthesized compounds were evaluated on the A431 human epidermoid carcinoma cell line. Structural differences influenced the light-induced toxicity of the test compounds markedly. Compared to the initial tetraphenyl aza-BODIPY derivative, the compound bearing two hydrophilic triethylene glycol side chains showed substantial, more than 250-fold, photodynamic activity with no dark toxicity. Our newly synthesized aza-BODIPY derivative, acting in the nanomolar range, might serve as a promising candidate for the design of more active and selective photosensitizers.
Topics & Concepts
ChemistryPhotodynamic therapyBODIPYIn vitroCombinatorial chemistryPhotosensitizerBiochemistryPhotochemistryOrganic chemistryFluorescencePhysicsQuantum mechanicsLuminescence and Fluorescent MaterialsNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine Chemistry