Therapeutic potential of the PI3K inhibitor LY294002 and PARP inhibitor Talazoparib combination in BRCA-deficient triple negative breast cancer cells
Gamze Güney Eskiler, Melek Öztürk
Topics & Concepts
PI3K/AKT/mTOR pathwayCancer researchTriple-negative breast cancerPARP inhibitorBreast cancerPoly ADP ribose polymeraseKinaseLY294002ChemistryBiologyApoptosisCancerCell biologyPolymeraseDNABiochemistryGeneticsPARP inhibition in cancer therapyDNA Repair MechanismsCRISPR and Genetic Engineering