Subcutaneous delivery of an antibody against SARS-CoV-2 from a supramolecular hydrogel depot
Catherine M. Kasse, Anthony C. Yu, Abigail E. Powell, Gillie A. Roth, Celine S. Liong, Carolyn K. Jons, Awua Buahin, Caitlin L. Maikawa, Xueting Zhou, Sawsan Youssef, Jacob E. Glanville, Eric A. Appel
Abstract
drug release assays and diffusion measurements indicate that the PNP hydrogels prevent burst release and slow the release of encapsulated antibodies. Delivery of bnAbs against SARS-CoV-2 from PNP hydrogels is compared to standard routes of administration in a preclinical mouse model. We develop a multi-compartment model to understand the ability of these subcutaneous depot materials to modulate the pharmacokinetics of released antibodies; the model is extrapolated to explore the requirements needed for novel materials to successfully deliver relevant antibody therapeutics with different pharmacokinetic characteristics.