4-octyl itaconate protects against oxidative stress-induced liver injury by activating the Nrf2/Sirt3 pathway through AKT and ERK1/2 phosphorylation
Ziyun Hu, Di Xu, Huihui Meng, Wenya Liu, Qi Zheng, Junsong Wang
Topics & Concepts
Protein kinase BOxidative stressSIRT3PI3K/AKT/mTOR pathwayLiver injuryChemistryPhosphorylationPharmacologyMAPK/ERK pathwaySignal transductionOxidative phosphorylationBiochemistryBiologySirtuinEnzymeNAD+ kinaseGenomics, phytochemicals, and oxidative stressDrug-Induced Hepatotoxicity and ProtectionLiver Disease and Transplantation