Recyclable mesalamine-functionalized magnetic nanoparticles (mesalamine/GPTMS@SiO<sub>2</sub>@Fe<sub>3</sub>O<sub>4</sub>) for tandem Knoevenagel–Michael cyclocondensation: grinding technique for the synthesis of biologically active 2-amino-4<i>H</i>-benzo[<i>b</i>]pyran derivatives
Mahdiyeh Partovi, Sobhan Rezayati, Ali Ramazani, Yavar Ahmadi, Hooman Taherkhani
Abstract
]pyran derivatives products in a short time with good yields. The presented procedure offers several advantages including gram-scale synthesis, good green chemistry metrics (GCM), easy fabrication of the catalyst, atom economy (AE), no use of column chromatography, and avoiding the generation of toxic materials. Furthermore, the nanocatalyst can be reused for 8 cycles with no loss of performance by using an external magnet.
Topics & Concepts
Knoevenagel condensationMalononitrileTandemDimedoneNanoparticleChemical engineeringCatalysisChemistryPyranNuclear chemistryMaterials scienceNanotechnologyOrganic chemistryComposite materialEngineeringMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis of Organic Compounds