Trifluoromethyl substitution enhances photoinduced activity against breast cancer cells but reduces ligand exchange in Ru(<scp>ii</scp>) complex
Austin P. Lanquist, Sayak Gupta, Kathlyn F. Al‐Afyouni, Malik H. Al‐Afyouni, Jeremy J. Kodanko, Claudia Turró
Abstract
Ru( ii ) complexes exhibit photoinduced exchange of coordinated CH 3 CN and photocytotoxicity against breast cancer cells highly dependent on the substituents of the ancillary triphenylphospine ligand.
Topics & Concepts
TrifluoromethylSubstitution (logic)ChemistryLigand (biochemistry)Breast cancerMCF-7Cancer researchStereochemistryCancerBiochemistryBiologyReceptorInternal medicineMedicineHuman breastOrganic chemistryAlkylComputer scienceProgramming languageMetal complexes synthesis and propertiesClick Chemistry and ApplicationsMetal-Catalyzed Oxygenation Mechanisms