Glycopolypeptide Nanocarriers Based on Dynamic Covalent Bonds for Glucose Dual-Responsiveness and Self-Regulated Release of Insulin in Diabetic Rats
Yanxia Wang, Yiting Fan, Minghao Zhang, Wen Zhou, Zhihua Chai, Hao Wang, Chunfeng Sun, Fan Huang
Abstract
generated from the glucose-GOx system, resulting in the rapid insulin release. After subcutaneous delivery of the insulin/GOx-loaded nanoparticles to diabetic mice, a significant hypoglycemic effect was observed over time. Cytotoxicity study, hemolysis assay, and histological analyses suggested that the nanoparticles showed excellent biocompatibility and safety. This work lays the important theoretical and technical foundations for expanding the scope of applications of nanocarriers in diabetes treatment.
Topics & Concepts
Glucose oxidaseChemistryNanocarriersEthylene glycolInsulinPhenylboronic acidBiocompatibilityNanoparticlePEG ratioCovalent bondCombinatorial chemistryDrug deliveryNanotechnologyBiochemistryOrganic chemistryMaterials scienceCatalysisMedicineInternal medicineFinanceEconomicsBiosensorAdvanced Drug Delivery SystemsHydrogels: synthesis, properties, applicationsGraphene and Nanomaterials Applications