Discovery of novel benzbromarone analogs with improved pharmacokinetics and benign toxicity profiles as antihyperuricemic agents
Zean Zhao, Jin Liu, L. Yuan, Zichao Yang, Peihua Kuang, Hui Liao, Jian Luo, Huancun Feng, Fengxin Zheng, Yongjun Chen, Ting Wu, Jiayin Guo, Ying Cao, Yang� Yang, Cuiting Lin, Qun Zhang, Jianjun Chen, Jianxin Pang
Topics & Concepts
ChemistryBenzbromaroneIn vivoPharmacologyPharmacokineticsIC50BioavailabilityADMECYP3A4ToxicityReabsorptionHyperuricemiaStereochemistryBiochemistryIn vitroUric acidCytochrome P450EnzymeOrganic chemistryBiotechnologyBiologyMedicineSodiumGout, Hyperuricemia, Uric AcidAlcohol Consumption and Health EffectsDrug-Induced Hepatotoxicity and Protection