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Discovery of novel benzbromarone analogs with improved pharmacokinetics and benign toxicity profiles as antihyperuricemic agents

Zean Zhao, Jin Liu, L. Yuan, Zichao Yang, Peihua Kuang, Hui Liao, Jian Luo, Huancun Feng, Fengxin Zheng, Yongjun Chen, Ting Wu, Jiayin Guo, Ying Cao, Yang� Yang, Cuiting Lin, Qun Zhang, Jianjun Chen, Jianxin Pang

2022European Journal of Medicinal Chemistry25 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryBenzbromaroneIn vivoPharmacologyPharmacokineticsIC50BioavailabilityADMECYP3A4ToxicityReabsorptionHyperuricemiaStereochemistryBiochemistryIn vitroUric acidCytochrome P450EnzymeOrganic chemistryBiotechnologyBiologyMedicineSodiumGout, Hyperuricemia, Uric AcidAlcohol Consumption and Health EffectsDrug-Induced Hepatotoxicity and Protection
Discovery of novel benzbromarone analogs with improved pharmacokinetics and benign toxicity profiles as antihyperuricemic agents | Litcius