Litcius/Paper detail

Geometrically Deformed and Conformationally Rigid Phosphorus Trisamides Featuring an Unsymmetrical Backbone

Niklas Beims, Tobias Greven, Marc Schmidtmann, Jarl Ivar van der Vlugt

2023Chemistry - A European Journal15 citationsDOIOpen Access PDF

Abstract

Abstract Nonclassical P(III) centers have attracted much attention in recent years. Incorporating a P(III) center in a rigid bicyclic platform offers a particularly attractive way to invoke significant geometric distortion of the phosphorus atom that may in turn induce unusual reactivity. Although still relatively scarcely explored, phosphorus centers enforced in a non‐ C 3 symmetry have gained significant traction lately. However, the current scaffolds are based on a relatively limited set of design principles and ligand platforms associated therewith. This work is focussed on the synthesis as well as versatile oxidation, addition and coordination chemistry of a geometrically distorted P(III) species featuring a synthetically modular, nonsymmetric trisamine platform derived from 2‐(methylamino)‐ N ‐(2‐(methylamino)phenyl)benzenesulfonamide.

Topics & Concepts

Ligand (biochemistry)Modular designChemistryDistortion (music)StereochemistryBicyclic moleculeCombinatorial chemistryPhosphorusReactivity (psychology)NanotechnologyPhysicsMaterials scienceComputer scienceReceptorOrganic chemistryOptoelectronicsCMOSOperating systemAmplifierMedicinePathologyAlternative medicineBiochemistrySynthetic Organic Chemistry MethodsOrganophosphorus compounds synthesisAsymmetric Hydrogenation and Catalysis