Histone methyltransferase G9a inhibitor-loaded redox-responsive nanoparticles for pancreatic ductal adenocarcinoma therapy
Jie‐Qin Wang, Liying Wang, Shijin Li, Tong Tong, Li Wang, Chen‐Song Huang, Qiong‐Cong Xu, Xi‐Tai Huang, Jianhui Li, Jun Wu, Wei Zhao, Xiaoyu Yin
Abstract
To overcome glutathione-induced malignant potential of pancreatic ductal adenocarcinoma (PDAC), redox-responsive nanoparticles based on glutathione depletion strategy were used to deliver histone methyltransferase G9a inhibitor for PDAC therapy.
Topics & Concepts
Pancreatic ductal adenocarcinomaRedoxCancer researchMethyltransferasePancreatic carcinomaNanoparticleChemistryMedicineInternal medicineMaterials sciencePancreatic cancerBiochemistryNanotechnologyInorganic chemistryMethylationCancerDNAEpigenetics and DNA MethylationPancreatic and Hepatic Oncology ResearchAdenosine and Purinergic Signaling