Deciphering and reprogramming the cyclization regioselectivity in bifurcation of indole alkaloid biosynthesis
Zhuo Wang, Yiren Xiao, Song Wu, Jianghua Chen, Ang Li, Evangelos C. Tatsis
Abstract
alkaloid biosynthesis and facilitating future synthetic biology applications. We anticipate that our work presents, for the first time, insights at the molecular level for plant P450 catalytic activity with a significant key role in the diversification of alkaloid metabolism, and provides the basis for designing new drugs.
Topics & Concepts
RegioselectivityEnzymeIndole testBiochemistryBiosynthesisCytochrome P450Indole alkaloidStereochemistryBiologyChemistryCatalysisAlkaloids: synthesis and pharmacologyPharmacogenetics and Drug MetabolismBerberine and alkaloids research