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RRx-001 ameliorates inflammatory diseases by acting as a potent covalent NLRP3 inhibitor

Yun Chen, Hongbin He, Bolong Lin, Yun Chen, Xianming Deng, Wei Jiang, Rongbin Zhou

2021Cellular and Molecular Immunology131 citationsDOIOpen Access PDF

Topics & Concepts

InflammasomePyrin domainExperimental autoimmune encephalomyelitisInflammationMedicineNeuroinflammationInnate immune systemPathogenesisPharmacologyImmunologyImmune systemInflammasome and immune disordersMacrophage Migration Inhibitory FactorIL-33, ST2, and ILC Pathways
RRx-001 ameliorates inflammatory diseases by acting as a potent covalent NLRP3 inhibitor | Litcius