Leishmania donovani Targets Host Transcription Factor NRF2 To Activate Antioxidant Enzyme HO-1 and Transcriptional Repressor ATF3 for Establishing Infection
Shriya Saha, Shalini Roy, Ananya Dutta, Kuladip Jana, Anindita Ukil
Abstract
We showed previously that antioxidant enzyme heme oxygenase 1 (HO-1) is critical for Leishmania survival in visceral leishmaniasis. HO-1 inhibits host oxidative burst and inflammatory cytokine production, leading to parasite persistence.
Topics & Concepts
Proinflammatory cytokineBiologyActivating transcription factorTranscription factorGene silencingLeishmania donovaniTumor necrosis factor alphaOxidative stressImmunologyMolecular biologyInflammationBiochemistryVisceral leishmaniasisGeneLeishmaniasisGenomics, phytochemicals, and oxidative stressResearch on Leishmaniasis StudiesSynthesis and Biological Evaluation