Histologic evaluation of activation of acute inflammatory response in a mouse model following ultrasound-mediated blood-brain barrier using different acoustic pressures and microbubble doses
Aurea Pascal, Ningrui Li, Kendra J. Lechtenberg, Jarrett Rosenberg, Raag D. Airan, Michelle L. James, Donna M. Bouley, Kim Butts Pauly
Abstract
Our study demonstrated that there were mild histologic changes and activation of the acute inflammatory response using PNPs ranging from 0.15 MPa to 0.20 MPa, independent of MB dose. However, when higher PNPs of 0.25 MPa or above were applied, the same applied PNP resulted in more severe and widespread histological findings and activation of the acute inflammatory response when using the higher MB dose. The potential activation of the inflammatory response following ultrasound-mediated BBB opening should be considered when treating patients to maximize therapeutic benefit.
Topics & Concepts
UltrasoundBlood–brain barrierInflammatory responseMedicineInflammationPathologyInternal medicineCentral nervous systemRadiologyUltrasound and Hyperthermia ApplicationsPhotoacoustic and Ultrasonic ImagingThermal Regulation in Medicine