Promotion of collagen mineralization and dentin repair by succinates
Wenjing Jin, Yeli Jin, Pengqiang Duan, Haiyan Wu, Leiqing Zhang, Qiaolin Du, Haihua Pan, Ruikang Tang, Changyu Shao
Abstract
. As expected, the SA-pretreated demineralized dentin obtained full remineralization within two days, whereas it took more than four days in the control group, and their mechanical properties were considerably enhanced compared with those of the demineralized one. The possible mechanism of the promotion effect of SA was ultimately illustrated, with SA modification strengthening the capacity of the collagen matrix to attract more calcium ions, which might create a higher local concentration that could accelerate the mineralization of collagen fibers. These findings not only advance the understanding of the vital role of small biomolecules in collagen biomineralization but also facilitate the development of an effective strategy to repair hard tissues.