Neurexin1⍺ differentially regulates synaptic efficacy within striatal circuits
M. Felicia Davatolhagh, Marc V. Fuccillo
Abstract
mice, driven by reductions in neurotransmitter release. In contrast, thalamic excitatory inputs to DMS exhibit relatively normal excitatory synaptic strength despite changes in synaptic N-methyl-D-aspartate receptor (NMDAR) content. These findings suggest that dysregulation of Nrxn1α modulates striatal function in an input- and target-specific manner.
Topics & Concepts
NeuroscienceExcitatory postsynaptic potentialMedium spiny neuronBasal gangliaIndirect pathway of movementDirect pathway of movementStriatumBiologySynaptic plasticityNeurotransmitterOptogeneticsAMPA receptorBiological neural networkDopamineGlutamate receptorInhibitory postsynaptic potentialReceptorCentral nervous systemBiochemistryNeuroscience and Neuropharmacology ResearchNeural dynamics and brain functionReceptor Mechanisms and Signaling