Simulated Gastric Digestion and In Vivo Intestinal Uptake of Orally Administered CuO Nanoparticles and TiO<sub>2</sub> E171 in Male and Female Rat Pups.
Ninell P. Mortensen, Maria Moreno Caffaro, Shyam Aravamudhan, Lakshmi Beeravalli, Sharmista Prattipati, Rodney W. Snyder, Scott L. Watson, Purvi R. Patel, F. Weber, Stephanie A. Montgomery, Susan J Sumner, Timothy R Fennell
Abstract
E171 was observed by hyperspectral imaging of intestinal cross sections. Brightfield microscopy showed that the number of immune cells increased in the intestinal tissue following NP administration. Orally administered NPs led to low intestinal uptake of NPs and an increase in immune cells in the small and large intestine, suggesting that oral exposure to NPs during early life may lead to irritation or a low-grade inflammation. The long-term impact of increased immune cells in the intestinal tract during early life is unknown.