Novel potent benzimidazole-based microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C4 synthase
Azize Gizem Ergül, Tuğçe Gür Maz, Christian Kretzer, Abdurrahman Olğaç, Paul M. Jordan, Burcu Çalışkan, Oliver Werz, Erden Banoğlu
Topics & Concepts
ChemistryATP synthaseBenzimidazoleLeukotriene C4MicrosomeProstaglandinLeukotrieneEnzyme inhibitorBiochemistryEnzymeProstaglandin E2StereochemistryPharmacologyImmunologyOrganic chemistryInternal medicineAsthmaBiologyMedicineInflammatory mediators and NSAID effectsEstrogen and related hormone effectsSynthesis and biological activity