Lipid droplet deposition in the regenerating liver: A promoter, inhibitor, or bystander?
Yuelei Hu, Ruilin Wang, Juan Liu, Yunfang Wang, Jiahong Dong
Abstract
Liver regeneration (LR) is a complex process involving intricate networks of cellular connections, cytokines, and growth factors. During the early stages of LR, hepatocytes accumulate lipids, primarily triacylglycerol, and cholesterol esters, in the lipid droplets. Although it is widely accepted that this phenomenon contributes to LR, the impact of lipid droplet deposition on LR remains a matter of debate. Some studies have suggested that lipid droplet deposition has no effect or may even be detrimental to LR. This review article focuses on transient regeneration-associated steatosis and its relationship with the liver regenerative response.
Topics & Concepts
Lipid dropletSteatosisLipid accumulationBystander effectDeposition (geology)Regeneration (biology)Liver regenerationCell biologyChemistryBiologyBiochemistryEndocrinologyImmunologyPaleontologySedimentLipid metabolism and biosynthesisLiver Disease Diagnosis and TreatmentLiver physiology and pathology