<i>N</i>-Trifluoromethylselenophthalimide, an Electrophilic Trifluoromethylselenolation Reagent and Its Application for the Synthesis of 4-Trifluoromethylselenolated Isoxazoles
Jia Wang, Xiao‐Xiao Lu, Run-Ping Yang, Bingbing Zhang, Zhi-Hao Xiang, Jiacheng Li, Lixia Liu, Shujun Chao, Xuefang Shang
Abstract
A new electrophilic trifluoromethylselenolation reagent, N -trifluoromethylselenophthalimide (Phth-SeCF 3 ), was developed. A strategy for the synthesis of 4-trifluoromethylselenolated isoxazoles through electrophilic trifluoromethylselenolation cyclization has been established by using Phth-SeCF 3 as an electrophilic reagent. Moreover, this protocol has the features of broad substrate scope, good functional group tolerance, and high yields.
Topics & Concepts
ElectrophileReagentChemistryCombinatorial chemistryFunctional groupSubstrate (aquarium)Organic chemistryCatalysisPolymerOceanographyGeologyFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsSulfur-Based Synthesis Techniques