A radical–radical cross-coupling reaction of xanthene with sulfonyl hydrazides: facile access to xanthen-9-sulfone derivatives
Sumit Das, Shantonu Roy, Arup Bhowmik, Writhabrata Sarkar, Imtiaj Mondal, Aniket Mishra, Shubhra Jyoti Saha, Sudip Karmakar, Indubhusan Deb
Abstract
metal-free radical-radical cross-coupling reaction of xanthenes and sulfonyl hydrazides. Using easily accessible starting materials, this methodology proceeds efficiently with a high degree of functional group compatibility and with a wide scope of both xanthenes and sulfonyl hydrazides under operationally simple reaction conditions. Mechanistic investigations revealed that sulfonyl radicals could be generated from sulfonyl hydrazides in the presence of TBHP under an oxygen atmosphere.
Topics & Concepts
SulfonylXantheneChemistrySulfoneMoietyRadicalCombinatorial chemistryCoupling reactionOrganic chemistryPhotochemistryCatalysisAlkylSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsRadical Photochemical Reactions