Mast Cell Activation Triggered by Retrovirus Promotes Acute Viral Infection
Shuting Song, Mengli Wu, Yi Zhang, Xiao Su, Jian‐Hua Wang
Abstract
T cells- and NK cells-mediated antiviral immune responses. The reconstruction of MCs in Sash mice promoted acute retroviral infection by regulating G-MDSCs functions and antiviral immune responses. Importantly, the administration of MC stabilizers to block cell degranulation elevated antiviral immune response and consequently suppressed retrovirus infection. This study uncovers a specific role of MCs in acute retroviral infection and elucidates the underlying immune-mechanisms. Targeting MCs may provide a novel approach for controlling acute infection by retroviruses.
Topics & Concepts
Immune systemBiologyDegranulationImmunologyVirologyVirusRetrovirusInnate immune systemReceptorBiochemistryMast cells and histamineImmune Cell Function and InteractionT-cell and B-cell Immunology